2024
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model. Bottom-Tanzer S, Corella S, Meyer J, Sommer M, Bolaños L, Murphy T, Quiñones S, Heiney S, Shtrahman M, Whalen M, Oren R, Higley MJ, Cardin JA, Noubary F, Armbruster M, Dulla CG. Cerebral Cortex. 2024. Jan 31; 34(2).
Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe. Cleary CM, Browning JL, Armbruster M, Sobriho CR, Strain ML, Jahanbani S, Soto-Perez J, Hawins VE, Dulla CG, Olsen ML, Mulkey DK. Communications Biology. 2024. March 28;7(1):373.
Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe. Cleary CM, Browning JL, Armbruster M, Sobriho CR, Strain ML, Jahanbani S, Soto-Perez J, Hawins VE, Dulla CG, Olsen ML, Mulkey DK. Communications Biology. 2024. March 28;7(1):373.
2023
Cortical Parvalbumin-Positive Interneuron Development and Function Are Altered in the APC Conditional Knockout Mouse Model of Infantile and Epileptic Spasms Syndrome. Ryner R, Derera ID, Armbruster M, Kansara A, Sommer ME, Pirone A, Noubary F, Jacob M, Dulla CG. Journal of Neuroscience. . 2023 Feb 22;43(8):1422-1440.
Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force. Morris G, Avoli M, Bernard C, Connor K, De Curtis M, Dulla CG, Jefferys JGR, Psarropoulou C, Staley KJ, Cunningham MO. Epilepsia. 2023. Oct; 64 (10): 2571-2585.
Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force. Morris G, Avoli M, Bernard C, Connor K, De Curtis M, Dulla CG, Jefferys JGR, Psarropoulou C, Staley KJ, Cunningham MO. Epilepsia. 2023. Oct; 64 (10): 2571-2585.
2022
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Ameroso D, Meng A, Chen S, Felsted J, Dulla CG, Rios M. Nature Metabolism. 2022. May; 4 (5):627-643.
Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Armbruster M, Naskar S, Garcia JP, Sommer M, Kim E, Adam Y, Haydon PG, Boyden ES, Cohen AE, Dulla CG. Nature Neuroscience. 2022. May; 25(5):607-616.
Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Armbruster M, Naskar S, Garcia JP, Sommer M, Kim E, Adam Y, Haydon PG, Boyden ES, Cohen AE, Dulla CG. Nature Neuroscience. 2022. May; 25(5):607-616.
2021
Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus. Rimmele TS, Li S, Andersen JV, Westi EW, Rotenberg A, Wang J, Aldana BI, Selkoe DJ, Aoki CJ, Dulla CG, Rosenberg PA. Front Cell Neurosci. 2021. Dec 29; 15:788262.
Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury. Dulla CG, Pitakanen A. Neurotherapeutics. 2021. July; 18(3): 1582-1601.
A team science approach to discover novel targets for infantile spasms (IS). CURE Infantile Spasms Consortium, CURE Staff, Lubbers L, Iyengar SS. Epilepsia Open. 2021. Dec 22;6 (1) 49-61.
Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap. Simonato M, Agoston DV, Brooks-Kayal A, Dulla C, Fureman B, Henshall DC, Pitkanen A, Theodore WH, Twyman RE, Kobeissy FH, Wang KK, Whittemore V, Wilcox KS. Nat Rev Neurol. 2021. April; 17(4):231-242.
Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury. Dulla CG, Pitakanen A. Neurotherapeutics. 2021. July; 18(3): 1582-1601.
A team science approach to discover novel targets for infantile spasms (IS). CURE Infantile Spasms Consortium, CURE Staff, Lubbers L, Iyengar SS. Epilepsia Open. 2021. Dec 22;6 (1) 49-61.
Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap. Simonato M, Agoston DV, Brooks-Kayal A, Dulla C, Fureman B, Henshall DC, Pitkanen A, Theodore WH, Twyman RE, Kobeissy FH, Wang KK, Whittemore V, Wilcox KS. Nat Rev Neurol. 2021. April; 17(4):231-242.
2020
In vivo KPT-350 treatment decreases cortical hyperexcitability following traumatic brain injury. Cantu D, Croker D, Shacham S, Tamir S, Dulla CG. Brain Inj. 2020 Sep 18;34(11):1489-1496.
The adenosine A1 receptor agonist WAG 994 suppresses acute kainic acid-induced status epilepticus in vivo. Klaft ZJ, Duerrwald LM, Gerevich Z, Dulla CG. Neuropharmacology. 2020 Oct 1;176:108213.
Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake. Armbruster M, Dulla CG, Diamond JS. Elife. 2020 Apr 30;9:e54441
Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions. Chang BS, Krishnan V, Dulla CG, Jette N, Marsh ED, Dacks PA, Whittemore V, Poduri A, NINDS/AES Epilepsy Researchs Benchmarks Stewards Committee. Epilepsy Currents. 2020 Jan-Feb.
2019
The path from scientific discovery to cures for epilepsy. Carvill GL, Dulla CG, Lowenstein DH, Brooks-Kayal AR. Neuropharmacology. 2019 Jul 10:107702.
Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury. Koenig JB, Cantu D, Low C, Sommer M, Noubary F, Croker D, Whalen M, Kong D, Dulla CG. JCI Insight. 2019 Apr 30;5. pii: 126506
Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation. Hanson E, Armbruster M, Lau LA, Sommer ME, Klaft ZJ, Swanger SA, Traynelis SF, Moss SJ, Noubary F, Chadchankar J, Dulla CG. J Neurosci. 2019 May 8;39(19):3611-3626.
2018
How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1-WG4 group of the ILAE/AES Joint Translational Task Force. Dulla CG, Janigro D, Jiruska P, Raimondo JV, Ikeda A, Lin CK, Goodkin HP, Galanopoulou AS, Bernard C, de Curtis M. Epilepsia Open. 2018 Nov 2;3(4):460-473.
Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy. Koenig JB, Dulla CG. Front Cell Neurosci. 2018 Oct 16;12:350.
Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors. Pirone A, Alexander JM, Koenig JB, Cook-Snyder DR, Palnati M, Wickham RJ, Eden L, Shrestha N, Reijmers L, Biederer T, Miczek KA, Dulla CG, Jacob MH. Front Synaptic Neurosci. 2018 Oct 12;10:35.
2017
α2δ-1 Signaling Drives Cell Death, Synaptogenesis, Circuit Reorganization, and Gabapentin-Mediated Neuroprotection in a Model of Insult-Induced Cortical Malformation. Lau LA, Noubary F, Wang D, Dulla CG. eNeuro. 2017 Nov 6;4(5). pii: ENEURO.0316-17.2017.
APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures. Pirone A, Alexander J, Lau LA, Hampton D, Zayachkivsky A, Yee A, Yee A, Jacob MH, Dulla CG. Neurobiol Dis. 2017 Feb;98:149-157.
Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK-WG4 report of the AES/ILAE Translational Task Force. Raimondo JV, Heinemann U, de Curtis M, Goodkin HP, Dulla CG, Janigro D, Ikeda A, Lin CK, Jiruska P, Galanopoulou AS, Bernard C. Epilepsia. 2017 Nov; 58 Suppl 4:40-52.
Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handing-induced seizures. Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL. Immunology. 2017. Dec; 152 (4):589-601.
APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures. Pirone A, Alexander J, Lau LA, Hampton D, Zayachkivsky A, Yee A, Yee A, Jacob MH, Dulla CG. Neurobiol Dis. 2017 Feb;98:149-157.
Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK-WG4 report of the AES/ILAE Translational Task Force. Raimondo JV, Heinemann U, de Curtis M, Goodkin HP, Dulla CG, Janigro D, Ikeda A, Lin CK, Jiruska P, Galanopoulou AS, Bernard C. Epilepsia. 2017 Nov; 58 Suppl 4:40-52.
Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handing-induced seizures. Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL. Immunology. 2017. Dec; 152 (4):589-601.
2016
Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. Armbruster M, Hanson E, Dulla CG. J Neurosci. 2016 Oct 5;36(40):10404-10415.
Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. Park KA, Ribic A, Laage Gaupp FM, Coman D, Huang Y, Dulla CG, Hyder F, Biederer T. J Neurosci. 2016 Jul 13;36(28):7464-75.
Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Hanson E, Danbolt NC, Dulla CG. Neurobiol Dis. 2016 May;89:157-68.
2015
Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Hanson E, Armbruster M, Cantu D, Andresen L, Taylor A, Danbolt NC, Dulla CG. Glia. 2015 April 27.
2014
Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Armbruster M, Hampton D, Yang Y, Dulla CG. Front Cell Neurosci. 2014 Sep 9;8:277.
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Andresen L, Hampton D, Taylor-Weiner A, Morel L, Yang Y, Maguire J, Dulla CG. Neurobiol Dis. 2014 Nov;71:305-16.
Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control. Cantu D, Walker K, Andresen L, Taylor-Weiner A, Hampton D, Tesco G, Dulla CG. Cereb Cortex. 2014 Mar 7. [Epub ahead of print]
A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR, Reimer RJ. Neuron. 2014 Feb 19;81(4):888-900.
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Andresen L, Hampton D, Taylor-Weiner A, Morel L, Yang Y, Maguire J, Dulla CG. Neurobiol Dis. 2014 Nov;71:305-16.
Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control. Cantu D, Walker K, Andresen L, Taylor-Weiner A, Hampton D, Tesco G, Dulla CG. Cereb Cortex. 2014 Mar 7. [Epub ahead of print]
A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR, Reimer RJ. Neuron. 2014 Feb 19;81(4):888-900.
2013
Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse. Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y. Hum Mol Genet. 2013 May 15;22(10):2041-54.
2012
Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. Dulla CG, Tani H, Brill J, Reimer RJ, Huguenard JR. Neurobiol Dis. 2012 Sep 11;49C:232-246.
2010 and before
Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. Tani H, Dulla CG, Huguenard JR, Reimer RJ. J Neurosci. 2010 Jan 27;30(4):1288-300.
Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. Dulla CG, Frenguelli BG, Staley KJ, Masino SA. J Neurophysiol. 2009 Sep;102(3):1984-93.
Imaging of glutamate in brain slices using FRET sensors. Dulla C, Tani H, Okumoto S, Frommer WB, Reimer RJ, Huguenard JR. J Neurosci Methods. 2008 Mar 15;168(2):306-19.
L-type calcium channels mediate acetylcholine receptor aggregation on cultured muscle. Milholland RB, Dulla C, Gordon H. Dev Neurobiol. 2007 Jul;67(8):987-98.
Adenosine and ATP link PCO2 to cortical excitability via pH. Dulla CG, Dobelis P, Pearson T, Frenguelli BG, Staley KJ, Masino SA. Neuron. 2005 Dec 22;48(6):1011-23.
